CEFOTAXIME
Opis
Soluble in water (0.05 gm/ 1 mL- clear, light yellow solution)
It generally has good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas. It is also effective against most Gram-positive cocci except for Enterococcus. It is active against penicillin-resistant strains of Streptococcus pneumoniae. It has modest activity against the anaerobic Bacteroides fragilis. In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime.
Product Description
Cefotaxime is a cephalosporin, which acts by interference of synthesis of peptidoglycan of the bacterial cell wall.
Biochem/physiol Actions
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Dane techniczne
Opakowanie | 500 mg |