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8-Hydroxyquinoline

nr kat.: H006-25G
Opakowanie: 25 g
Cena brutto: 293,97 zł 293.97
Cena netto: 239,00 zł
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Producent: TOKU-E
nr kat.: H006-25G

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

8-Hydroxyquinoline is a quinolone compound and antifungal with chelating properties.  It is a natural product found in the root exudate of the invasive plant Centaurea diffusa.  When in aqueous solution, it reacts with metal ions, forming 8-hydroxyquinoline-chelate complexes.  The complexes and the heterocycle itself have disinfectant properties.  When in alcohol, the solution can be used in liquid bandages.  Its halogenated derivatives can be used as anti-infectives. 8-Hydroxyquinoline is freely soluble in ethanol, acetone, chloroform, and benzene but is insoluble in water.

Cas Number: 148-24-3

Molecular Formula: C9H7NO

Molecular Weight: 145.16

Mechanism of Action: 8-Hydroxyquinoline is a RNA synthesis inhibitor that interferes with transcription. The antifungal activity appears to be structurally related but is not yet characterized.

Storage Conditions: 2-8 °C

Spectrum: Effective against fungi including Trichophyton mentagrophytes, Myrothecium verrucaria, and Trichoderma viride

Microbiology Applications:

8-Hydroxyquinoline can inhibit RNA synthesis in yeast cells by chelating essential divalent ions Mn2+ and Mg2+ required for RNA polymerase activity.

Plant Biology Applications:

8-Hydroxyquinoline is a floral preservative for cut flowers, increasing vase life by ~ 40% (Elgimabi and Ahmed, 2009) (Hojjati, 2007).

8-Hydroxyquinoline is a chelator of available iron and this property can be exploited by using the compound as a selective agent in low-iron media to screen for plant growth-stimulating and antagonistic fluorescent pseudomonads (Geels et al, 1985).

Eukaryotic Cell Culture Applications:

8-Hydroxyquinoline can be fluorinated to increase its activity as a metal ionophore and therefore is a  promising diagnostic tool as a metal-binding agent capable of dissolving amyloid-beta (Aβ) deposits of zinc, copper and iron involved in the metal hypothesis of Alzheimer’s disease (Liang SH et al, 2015).

Source: Synthetic

Water Content (Karl Fischer): ≤0.5%

Assay: ≥99.0%

Residue On Ignition: ≤0.5%

Heavy Metals: Pb ≤ 0.001%

Solubility: Freely soluble in ethanol, acetone, chloroform, and benzene. Insoluble in water.

Sulfated Ash: ≤0.2%

Purity Level: ≥99.0%

References:

Elgimabi MN and Ahmed OK (2009) Effects of bactericides and sucrose-pulsing on vase life of rose cut flowers (Rosa hybirida). Bot. Res. Intl. 2 (3):164-168

Fraser RS and Creanor J (2012)  The mechanism of inhibition of ribonucleic acid synthesis by 8-hydroxyquinoline and the antibiotic Lomofungin. Biochem. J.  147(3):401-410

Geels FP, Schmidt DL and Schippers B (1985)  The use of 8-hydroxyquinoline for the isolation and prequalification of plant growth-stimulating rhizosphere pseudomonads. B. Biol Fert Soils 1(4):167-173 

Hojjati Y, Khalighi A and Farokhzad AR (2007)  Chemical treatments of Eustoma cut flower cultivars for enhanced vase life. J. Agric. and Soc. Sci. 1813–2235

Liang SH et al (2015)  Novel fluorinated 8-Hydroxyquinoline based metal ionophores for exploring the metal hypothesis of Alzheimer’s Disease. ACS Med. Chem. Lett. 6(9):1025-1029

Vivanco JM et al (2004)  Biogeographical variation in community response to root allelochemistry: Novel weapons and exotic invasion. Ecol. Lett. 7(4):285-292

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